Hi! I just started metformin Wednesday, so we’re twins! I have a 2000 mg rx, but doc told me to start at 500, up to 1000, up to 1500, up to 2000 basically once the smaller dose felt comfortable. I took 500 on Wednesday and Thursday and had no real issue other than kinda what you described. Medical Watch Digest for March 18 Metformin & Brain Development A popular drug, prescribed during pregnancy, could alter brain development in a growing baby. The …Metformin and Headache. I recently gave blood to look at my general blood values. My doctor said you have insulin resistance and prescribed Metformin 1000mg. (said you are not diabetic) The drug was taken alone after dinner. The next day, in the afternoon, the right side of my head began to ache. It went on for 2-3 hours and passed. 4. prohaska. • 3 yr. ago • Edited 3 yr. ago. Under no circumstances take Met on an empty stomach. You will have horrible painful cramps and "soil" your clothes, sheets, furniture. Do not do it. Take it the moment you eat a meal. Eat something low to no carb, then take it. Have a carrot or two with peanut butter. Reddit is a popular social media platform that has gained immense popularity over the years. With millions of active users, it is an excellent platform for promoting your website a...It’s not listed in the DDI section of the prescribing information (google paxlovid PI if you want to read it). I also know diabetics who take metformin who were prescribed paxlovid, so there shouldn’t be an issue, but check with your doctor to make sure they don’t have problems with anything else you might be taking. 3.Reddit has raised a new funding round, totaling $250 million. This is the company’s Series E round of financing, and it comes hot on the heels of renewed public attention on the si...Every single set of diabetes guidelines (the ADA, AACE, ACP, etc) puts metformin (the sole remaining drug in the "biguanide" class) as #1 amongst all those options. It's weight neutral (or even helps cause weight loss), super cheap, extremely effective, and typically very well tolerated (except for some transient nausea or diarrhea that for ...let me start by saying I take a crap ton of medications. Mostly for MCAS and as a former nurse practitioner, I believe that most MCAS patients will need medications to control symptoms. That said, my stomach symptoms of MCAS did get worse on Metformin. I say give it a try. You can always stop taking it and it will leave your system pretty quickly. I’ve taken 500mg of Metformin and Mounjaro together the entire time I’ve been on it. (Now on the 12.5 dose.) I’ve steadily lost 1 to 2 lbs a week and my A1C, cholesterol and glucose numbers are awesome! The only side effect I’ve had has been heartburn - other than that, I feel great. I'm on metformin and Mounjaro. metformin for non diabetic reddit Reply reply ... Embaressed to say I have no idea how to use reddit but here I am. I'm trying to adopt/borrow a diabetic cat. I tried an online pharmacy but it wanted me to upload documentation of a used box/ old prescription to verify.Metformin doesnt decrease/increase insulin secretion. What it does is that it changes the response of tissues to insulin. Its an insulin sensitizer, meaning it will cause tissues to take up more glucose from blood. This is why its primary use is in type2 diabetes, these people have tissues that are "insulin resistant".Apr 14, 2565 BE ... Metformin and prediabetes · Your doctor will tell you if you need to increase the metformin. I was on 500mg of metformin for awhile and it was ...A1c was 5.8 on metformin. Type 2. Last time, my A1c was 6.1, so doing better. I was worried that it would be high, since I haven't been managing myself with carbs as strictly as before. That's a good number; I thought it was going to be higher, actually. My primary was happy about it and wants to check my glucose levels every 6 …Metformin tried to kill me via my liver/liver enzymes- my main symptoms were severe fatigue and feeling like I swallowed tacks for hours after each dose… progressed after only a week into thinking I had kidney stones coming on, only it was a significantly enlarged liver. So, when my dad was diagnosed, he was put on metformin plain. He started having bowel problems like you. We didn't connect it to his medication for a long time. Fast forward 10 years. I'm diagnosed with T2. I start metformin plain, and the side effects don't go away. I mention it to my doctor, and he switched me to metformin ER. My side effects ... It’s possible to take metformin and berberine together - just depends on the dosage. I take 2000mg of berberine a day which is equivalent to what I had originally been prescribed in metformin (2000mg). I cannot tolerate a max metformin dose, but at one point I was taking half and half - 1000mg of metformin plus 1000mg of berberine, which ... Berberine seems better for directly working on increasing insulin sensitivity, which then helps lower blood sugar indirectly. Metformin on the other hand seems to lower blood sugar better than berberine, though it may not be as good at increasing insulin sensitivity directly. I still feel low key hunger on metformin, though it's still better ...Long & boring story short, I’ve been on metformin just under a week - and I’ve had awful all-body itching and hives twice. Each time just after taking metformin. I am going to speak to my nurse ASAP, I’m not seeking medical advice. Just wondering what people’s experiences are ☺️. Commonly causes gastro issues.Switching to ER Metformin went from impossible to sort of workable, but I was still vomiting at least once a week. When I got health insurance I switched to non-generic Metformin and that eliminated the vomiting enough that I could actually take the full dosage. Unfortunately taking 2000 mg daily is how I discovered I can't handle it... GI problems started as soon as I was taking the 2 pills of metformin a day + paxlovid. Inhad the worst diarrhea and was nauseous the entire day. So I stopped metformin. I ended up getting covid rebound 4 days after my last dose of paxlovid. I do not know if metformin helps prevent rebounds. If they did and I knew it, I would've continued the ... I was diagnosed in November and started in late Nov/early Dec 2023 and am taking 1000mg daily. I’ve lost ~10lbs since I started. I have always been pretty active 3-5 days a week …phentermine and metformin. Type 2. I was put on phentermine to loose weight and metformin to lower my blood sugar levels. I was told by the dr (and it’s printed on the label) to take phentermine 15 minutes before I eat and metformin when I’m done eating. After reading the enclosed prescription information papers that is not what it says.Make sure you're taking it with food. Your doctor should have started you on a low dose to build your tolerance. For example, 500mg once a day for a week, then 500mg 2x a day. Then blood work after a certain amount of time to see if you need a higher dose. At that point, if increased, 1000mg in am, 500 at night for a week, then 1000mg 2x a day.Patients treated with metformin lost on average 10-14 pounds (5.6% to 6.5% of body weight) compared to controls who gained 6-8 pounds during the same time period. What’s interesting is that the percentage of weight loss achieved in each individual was independent of age, sex, or BMI. This means that if you are …METFORMIN AND BERBERINE COMPARISON. Been on metformin for about a fortnight and built to one tablet in the AM and one in the PM now seem to be getting headaches every day. Looked into Berberine as a natural alternative, seems like its got general good reviews. Is there anyone out there who has used berberine and …Make sure you're taking it with food. Your doctor should have started you on a low dose to build your tolerance. For example, 500mg once a day for a week, then 500mg 2x a day. Then blood work after a certain amount of time to see if you need a higher dose. At that point, if increased, 1000mg in am, 500 at night for a week, then 1000mg 2x a day.It’s just me who notices. Not sure if this is your experience, but those are my thoughts! I found that after a few months on Metformin that the symptoms of severe pms during the luteal phase resulted in me feeling more mood swingy. I now take more b vitamins to make up for what I suspect Metformin is depleting somewhat.r/InsulinResistance. r/InsulinResistance. Discussions about defeating Insulin Resistance, the cause of most disease. MembersOnline. •. Comfortable_You_3280. Metformin and Cravings. I was diagnosed with PCOS and insulin resistance last week, and I've been taking 500mg metformin since Saturday. Since then my constant insatiable carb and sugar ... After four months of diet and exercise I had lost 13 kg and was no longer prediabetic, so she took me off metformin. I continued to lose weight (15 more kg) unmedicated with normal sugar levels and controlled PCOS. I do believe that metformin helped me in the first part of my journey by managing my insulin resistance. Even on Metformin+Jardiance eating low carb would still regularly cause my blood sugar to spike to 160-200 after a meal. It's been quite a while since I've had a spike over 160 since Ozempic. Side effects wise, I was having stomach pains with Metformin initially, but after switching to the extended release version those went away.Discover how the soon-to-be-released Reddit developer tools and platform will offer devs the opportunity to create site extensions and more. Trusted by business builders worldwide,...I stopped taking it for a week and lost 8 pounds, but my blood sugar went way up. Made me gain 20 lbs and I stopped taking it and now I haven't gain any lbs after that. Fasting glucose is about a 5.5-6 but my a1c is more of a 5.5, which is more accurate. No metformin but I’m on 6 units of degludec insulin.Apr 20, 2565 BE ... The dark side of metformin · Metformin increases lactic acid levels at rest. · Metformin blunts some of the beneficial responses to exercise (&nbs... The studies I have read involving NAC as a metformin substitute for people with PCOS took it in addition to Inositol so don't forget to use that too. I used this combination for about 3 months before I found the supplements were just prohibitively expensive for me. The studies show that it takes at least 6 months of this regimen to show ... A1c was 5.8 on metformin. Type 2. Last time, my A1c was 6.1, so doing better. I was worried that it would be high, since I haven't been managing myself with carbs as strictly as before. That's a good number; I thought it was going to be higher, actually. My primary was happy about it and wants to check my glucose levels every 6 …Metformin is a drug that is being studied for its potential to treat liver fibrosis, a condition where the liver becomes stiff and scarred. This study found that metformin affects the mitochondria (the powerhouses of cells) in a certain type of liver cell called hepatic stellate cells (HSCs) and helps to decrease the severity of liver fibrosis.Apr 14, 2565 BE ... Metformin and prediabetes · Your doctor will tell you if you need to increase the metformin. I was on 500mg of metformin for awhile and it was ...Well, that’s actually a big reason why the trial has been proposed: according to a recent study,1 metformin seems to extend lifespan, which is the ultimate acid test of intervention against aging. Specifically, it has been reported that diabetics taking metformin live longer, on average, than non-diabetics: in other words, that the overall ...If you think that scandalous, mean-spirited or downright bizarre final wills are only things you see in crazy movies, then think again. It turns out that real people who want to ma...Metformin was then used in a separate study to achieve the same effect without the need to fast. A human study used a small sample with a 7 day fast and reviewed 6 months later also showing positive results. Clemastine has shown improvement in ocular health in MS studies - which indicated remyelination at doses of 5.3mg daily.Oct 24, 2565 BE ... Metformin is not perfect and it's not a miracle drug. Exercise (specifically strength building) and low carb are going to be your long term best ...Dec 25, 2565 BE ... Metformin is not like ozempic. It kinda works as a mild appetite suppressant. You have to put in the work to. Intermittent fasting n low calorie ...Type 2. I wanted to share my personal experience with Ozempic vs. Metformin to see if anyone else has similar results. For a couple of years I'd been taking Metformin and had good results. In particular, with regular exercise, normal weight, and fairly strict control of my diet, I had achieved an A1C level of 6.4 as of December 2022.Metformin may decrease vitamin B12 levels and increase levels of homo‐cysteine, leading to higher cardiovascular risk. In a trial where 196 patients received a mean dose of Metformin of 2.1g homocysteine increased by an average of 0.40 μmol and vitamin B12 decreased by 4.40 pmol.The fact that metformin and sprint exercise affect your body weight through the same pathway is both weird and interesting. Long and his colleagues also analyzed …The fact that metformin and sprint exercise affect your body weight through the same pathway is both weird and interesting. Long and his colleagues also analyzed …Discover how the soon-to-be-released Reddit developer tools and platform will offer devs the opportunity to create site extensions and more. Trusted by business builders worldwide,...Things that control blood glucose via the same mechanisms will have similar hormesis-reducing effects. Although the AMPK activation from berberine is less than metformin. I personally use and really like berberine/DHB. Haven't noticed any decreases in endurance or lactate tolerance as is commonly reported with metformin. Metformin does have some adverse reactions. Diarrhea, flatulence, vomiting and nausea are common early reactions but no more usual in t1 than t2. Vitamin B12 deficiency is another one. Some very uncommon serious reactions are megaloblastic anemia, lactic acidosis, and hepatic toxicity. They are for blood sugar control. Higher doses of ozempic for weight loss are off label use, this is still a diabetic drug. Ozempic causes your body to release more insulin when necessary, but metformin makes your body more sensitive to insulin, thus bringing down fasting insulin and requiring your body to produce less of it to get a normal ...Patients treated with metformin lost on average 10-14 pounds (5.6% to 6.5% of body weight) compared to controls who gained 6-8 pounds during the same time period. What’s interesting is that the percentage of weight loss achieved in each individual was independent of age, sex, or BMI. This means that if you are …It’s not listed in the DDI section of the prescribing information (google paxlovid PI if you want to read it). I also know diabetics who take metformin who were prescribed paxlovid, so there shouldn’t be an issue, but check with your doctor to make sure they don’t have problems with anything else you might be taking. 3.I personally have never had any issues drinking while on metformin. But I also havent had any adverse reactions to metformin in general. To he safe, id say just take it slow if youre going to drink. Id try to avoid getting super wasted just to be on the safe side, but I think youll be okay either way. Icy-Thanks-3170.Side effects included: extreme diarrhea, headaches, nausea, stomach pains, brain fog, a feeling of brain fuzziness (like pins and needles but sometimes sharper), and probably other things I've blocked out of my mind at this point because it was the worst month of my life. 14 votes, 30 comments. true.. METFORMIN AND BERBERINE COMPARISON. Been on metformin for about a fortnight and built to one tablet in the AM and one in the PM now seem to be getting headaches every day. Looked into Berberine as a natural alternative, seems like its got general good reviews. Is there anyone out there who has used berberine and …What to Know Before You Take It. Are you struggling to lose weight? Metformin can do more than improve blood sugar control — it may also help you lose … However, after 1 month of treatment, a significant decrease in total, free, and bioavailable testosterone was observed in the metformin group compared with baseline levels (P <.05). No significant decrease was observed in the control group.”. Testosterone increases at first then drops after a month. xxthelightxx • 1 mo. ago. Metformin is used to treat high glucose numbers, he might just be trying to lower his glucose to burn more fat. It has serious gut issues when imporperly used. UghAnotherMillennial • 1 mo. ago. It can also block b12 absorption in some cases. Bella_Climbs • 1 mo. ago.Metformin works in the colon so that is why most people get upset stomach and diarrhea w cramping. I had to start very, very slow. Regimen that I recommend to patients is start 250 mg at bedtime every NIGHT or every other night. Wait 10 days to increase because used stomach starts a few days into regimen. 4. prohaska. • 3 yr. ago • Edited 3 yr. ago. Under no circumstances take Met on an empty stomach. You will have horrible painful cramps and "soil" your clothes, sheets, furniture. Do not do it. Take it the moment you eat a meal. Eat something low to no carb, then take it. Have a carrot or two with peanut butter. I was diagnosed with Type 2 diabetes three years ago, and was prescribed 1000 mg Metformin in the morning and night. My A1C number was 8.0 (fasting glucose 180) ...Here's what the ADA says: 9.7 Long-term use of metformin may be associated with biochemical vitamin B12 deficiency, and periodic measurement of vitamin B12 levels should be considered in metformin-treated patients, especially in those with anemia or peripheral neuropathy. B.It’s just me who notices. Not sure if this is your experience, but those are my thoughts! I found that after a few months on Metformin that the symptoms of severe pms during the luteal phase resulted in me feeling more mood swingy. I now take more b vitamins to make up for what I suspect Metformin is depleting somewhat. The studies I have read involving NAC as a metformin substitute for people with PCOS took it in addition to Inositol so don't forget to use that too. I used this combination for about 3 months before I found the supplements were just prohibitively expensive for me. The studies show that it takes at least 6 months of this regimen to show ... Metformin and Headache. I recently gave blood to look at my general blood values. My doctor said you have insulin resistance and prescribed Metformin 1000mg. (said you are not diabetic) The drug was taken alone after dinner. The next day, in the afternoon, the right side of my head began to ache. It went on for 2-3 hours and passed.AmericanNinjaWorrier. • 7 yr. ago. I have PCOS and do notice an increase in energy (which leads to better focus) when I'm taking Metformin consistently. My best guess is that blood sugar issues contribute to low energy, and low energy makes it harder to focus and do all the other stuff your brain finds difficult. r/ADHD.Alternative to metformin, preferably injectables. Prediabetic. Hi all, I was just diagnosed with pre-diabetes, and after a week on Metformin I can't tolerate it. The acid reflux was getting better until last night, when it came back with a vengeance, along with really bad nausea, stomach pain, a terrible metallic taste and a sore tongue (which ...Metformin —> Berberine. My doctor switched me from Metformin (500mg bid) to Berberine (500mg tid) because I need to get my blood sugar under control and I cannot tolerate the Metformin (stomach pain, diarrhea). Only side effects from the Berberine (I’m on Day 5) are soft stool and peeing all the damn time.Yes. There are definitely case reports of metformin overdose resulting in severe lactic acidosis. Whether associated with hypoperfusion (Type A, like in septic shock) or other causes (Type B, drugs like metformin) significantly elevated lactate (>5) is independently associated with poorer outcomes. The mechanism as u/CycIizine has described.Learn about metformin, a medication for type 2 diabetes that improves insulin sensitivity and lowers blood sugar levels. Find out how it works, its benefits and risks, …Metformin increases lactic acid levels at rest. This seems to be because metformin is actually a mitochondrial toxin. This is the reason why Peter Attia stopped metformin use. Metformin blunts some of the beneficial responses to exercise (esp. the upregulation in anti-oxidant systems).Metformin plus sulfonylureas vs. glucagon-like peptide-1 receptor agonists All-cause mortality: 1.15 (0.49 to 2.67) Metformin plus sulfonylureas vs. dipeptidyl-peptidase-4 …Takeaway. Metformin is used to help treat type 2 diabetes. Mild side effects, such as nausea, vomiting, and diarrhea, are common and go away with time. But, some …Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American …I have a shit tonne of energy. Abdominal pain is listed as a side effect. Some people just can’t adjust to metformin. You may need a combo drug or ask about Forxiga. I took that (I’m now in a combo forxiga/metformin) and it worked well for me. (FTR I …On a more serious note, it's bullshit. If metformin was a miracle drug it would be very widely known and publicised as its been studied since the 50's. There are no drugs like that. I am not an expert, but new benefits of old drugs are discovered all the time. In fact, metformin's itself has come in and out of favor repeatedly due to changing ...I take 1000 in the morning, and 1000 at night. The metformin half life in your bloodstream will remain the same no matter what time you take it. The difference will be how quickly and how completely your body absorbs it depending upon if your stomach is full or empty. According to the FDA, it is absorbed slightly faster and with slightly higher ...Using their understanding of clinical research, the authors recommended that the GLP-1 receptor agonists should be first-line therapy in type 2 diabetes. They invoke …Metformin works in the colon so that is why most people get upset stomach and diarrhea w cramping. I had to start very, very slow. Regimen that I recommend to patients is start 250 mg at bedtime every NIGHT or every other night. Wait 10 days to increase because used stomach starts a few days into regimen. After four months of diet and exercise I had lost 13 kg and was no longer prediabetic, so she took me off metformin. I continued to lose weight (15 more kg) unmedicated with normal sugar levels and controlled PCOS. I do believe that metformin helped me in the first part of my journey by managing my insulin resistance. Been on Metformin for 4 years- consistent diarrhea and loose stools. I was diagnosed as type 2 in April 2015. I cannot honestly remember the last time I had a normal stool. I consistently either have diarrhea or very loose stools. My doctor prescribed me 1000mg twice daily and I'm fairly certain they're NOT the extended release as my medicine ...Unlike Twitter or LinkedIn, Reddit seems to have a steeper learning curve for new users, especially for those users who fall outside of the Millennial and Gen-Z cohorts. That’s to ...Metformin does have some adverse reactions. Diarrhea, flatulence, vomiting and nausea are common early reactions but no more usual in t1 than t2. Vitamin B12 deficiency is another one. Some very uncommon serious reactions are megaloblastic anemia, lactic acidosis, and hepatic toxicity.Type 2. I wanted to share my personal experience with Ozempic vs. Metformin to see if anyone else has similar results. For a couple of years I'd been taking Metformin and had good results. In particular, with regular exercise, normal weight, and fairly strict control of my diet, I had achieved an A1C level of 6.4 as of December 2022.The action of this class of drug, though reinforces the foundational cause of type 2 diabetes, hyperinsulinemia. Type 2s and pre-diabetics have too much insulin. The cells stop listening to it to take in glucose, so the pancreas makes more. This class of drug causes the pancreas to make even more. It’s a cheap drug.Of course it's similar to fasting. But I think you're better off eating less than with metformin. Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older …You do need to make lifestyle changes with or without metformin, but personally if I were you, I would take metformin because your insulin is through the roof. A healthy fasting insulin level is five or under. Your HOMA-IR is also very concerning; healthy is around one and over three is significant IR. So I think you just want to get things ... The tummy issues can vary if you have a generic form, from my experience. I found that out the not-so-fun way. When I first started Metformin (also for the damn PCOS), I lost about 15lbs, but that was it. Berberine seems better for directly working on increasing insulin sensitivity, which then helps lower blood sugar indirectly. Metformin on the other hand seems to lower blood sugar better than berberine, though it may not be as good at increasing insulin sensitivity directly. I still feel low key hunger on metformin, though it's still better ... I have a shit tonne of energy. Abdominal pain is listed as a side effect. Some people just can’t adjust to metformin. You may need a combo drug or ask about Forxiga. I took that (I’m now in a combo forxiga/metformin) and it worked well for me. (FTR I …I like the smell of spirinolactone, it smells like mint. I take spironolactone, metformin, and bupropion SR and I have never noticed a smell with any them. I even get them all filled at the same time, my poor pharmacy tech.. Omg maybe if you ask your tech or pharmacist they might let you smell it.Metabolic abnormalities, including insulin resistance and dyslipidemia (particularly low high-density lipoprotein levels), frequently coexist with obesity. ---1